Identification of genetic modifiers in muscular dystrophy
Students will get an opportunity to identify genetic modifiers of Duchenne muscular dystrophy (DMD) by whole genome sequencing analysis of patient muscle samples. Whole genome sequencing and analysis will be performed by a collaborator at HudsonAlpha. Students will test genetic modifiers in human muscle cell cultures of patients to test function. Additionally, followup of putative genetic modifiers will be undertaken in zebrafish models of Duchenne muscular dystrophy. Students will gain valuable experience in working in a genetic/molecular biology lab with translational research as the main focus. Additional, projects involving epigenetic modifiers (non-coding RNAs/ncRNAs) as modifiers of muscular dystrophy disease pathologies are available.
Contact Information
Matthew Alexander
malexander@peds.uab.edu
205-934-7790
